Abstract #1183

Distribution of intravenous Gadolinium-based contrast agents (GBCA) in human olfactory regions in healthy subjects

Xinyi Zhou^1,2,3, Sofia Garcia Del Barrio Cervera^1,2,3, Yuanqi Sun^1,2,3, Wei Li^1,2, Licia Pacheco-Luna⁴, Haris I. Sair⁴, Adrian Paez¹, Linda Knutsson^1,5, Peter C.M. van Zijl^1,2,3, Vidyulata Kamath⁶, Arnold Bakker^5,6, Bryan Ward⁷, and Jun Hua^1,2

¹F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ²Neurosection, Division of MRI Research, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States, ⁴Division of Neuroradiology, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁵Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁶Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁷Department of Otolaryngology - Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Synopsis

Keywords: Neurofluids, Neurofluids, olfactory, DSC/DCE perfusion

Motivation: Animal studies show that the olfactory pathway is a primary CSF clearance route. However, human studies using intrathecal-GBCA show that the olfactory route may be less involved in CSF clearance in humans. As most GBCA-enhanced MRI exams are still performed using intravenous-GBCA, it is essential to investigate GBCA dis-tribution in human olfactory regions after intravenous GBCA administration.

Goal(s): To measure intravenous-GBCA-induced signal changes in olfactory regions.

Approach: Dynamic-susceptibility-contrast-in-the-CSF (cDSC) MRI was performed in 25 healthy subjects.

Results: Significant MR signal changes were detected in the olfactory regions following intravenous-GBCA. Extracranial regions showed more significant GBCA-induced changes than intracranial regions.

Impact: GBCA-induced cDSC signal changes were detected in olfactory regions of healthy subjects following intravenous GBCA administration. Extracranial regions showed more significant changes than intracranial regions, stressing the importance of separating these areas when studying GBCA distribution using intravenous injection.

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