Keywords: Neurofluids, Neurofluids
Motivation: Neurofluids dynamics are hypothesized to enable brain metabolite waste clearance pathways for healthy brain function including coupling between arterial, venous, and CSF fluid flow.
Goal(s): To enable quantification of arterial, venous and CSF flow simultaneously leveraging interleaved multi-Venc phase contrast encoding and spiral sampling.
Approach: A four-point velocity encoding scheme was integrated into a 2D golden angle spiral phase contrast sequence and used in studies of healthy subjects. The flow encoding collects multiple first moments at a fixed echo time.
Results: The multi-Venc encoding scheme allowed for simultaneous measures of cardiac-resolved arterial, venous, and CSF flow.
Impact: This work demonstrates a method for simultaneous arterial, venous, and CSF flow imaging for imaging neurofluid dynamics and their response to stimuli, challenges, and transient patient states.
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