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Abstract #1200

3D Hybrid Deep Learning Solution for Subcortical Segmentation

Aaron Cao1, Vishwanatha Rao2, Xinru Liu3, and Jia Guo4,5
1Valley Christian High School, San Jose, CA, United States, 2Department of Biomedical Imaging, Columbia University, New York City, NY, United States, 3The Village School, Houston, TX, United States, 4Department of Psychiatry, Columbia University, New York City, NY, United States, 5Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York City, NY, United States

Synopsis

Keywords: Analysis/Processing, Neuro

Motivation: For subcortical brain segmentation, the most widely accepted tools like FreeSurfer are slow and inefficient for large datasets, while faster methods often sacrifice accuracy and reliability.

Goal(s): In this study, we propose a novel deep learning based alternative and achieve consistent state-of-the-art performance within reasonable processing times.

Approach: Our model, TABSurfer, utilizes a 3D patch-based approach with a hybrid CNN-Transformer architecture.

Results: We evaluated TABSurfer against FreeSurfer ground truths across various T1w MRI datasets, consistently demonstrating strong performance over a leading deep learning benchmark, FastSurferVINN. Then, we validated TABSurfer on a manual reference, outperforming both FreeSurfer and FastSurferVINN based on the gold standard.

Impact: Our proposed deep learning model, TABSurfer, demonstrated state-of-the-art subcortical segmentation performance and utility. TABSurfer displayed reliability across numerous datasets and outperformed well established traditional and deep learning tools in FreeSurfer and FastSurferVINN.

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Keywords