Abstract #1239

Resting-state changes along the cortical depth detected during evolution of major depressive disorder

Patricia Pais-Roldán¹, Seong Dae Yun¹, Shukti Ramkiran^1,2, Ravichandran Rajkumar^1,2,3, Jana Hagen², Areej Al Okla¹, Tanja Veselinovic^1,2, Gereon Schnellbächer², Irene Neuner*^1,2,3, and N. Jon Shah*^1,3,4,5

¹Institute of Neuroscience and Medicine 4, INM-4, Forschungszentrum Jülich, Jülich, Germany, ²Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH, Aachen, Germany, ³JARA - BRAIN - Translational Medicine, Aachen, Germany, ⁴Department of Neurology, RWTH Aachen University, Aachen, Germany, ⁵Institute of Neuroscience and Medicine 11, INM-11, JARA, Forschungszentrum Jülich, Jülich, Germany

Synopsis

Keywords: Psychiatric Disorders, Brain Connectivity, Laminar connectivity, depression

Motivation: The relative contribution of each cortical depth to the network disturbances coupled with depression remains unexplored.

Goal(s): We aim to identify changes in connectivity along the cortical thickness during depression recovery.

Approach: We use high-resolution, large-coverage EPIK to functionally map the brain of patients before and after treatment and perform cortical-depth specific analysis of network connectivity.

Results: Changes in connectivity linked to depression treatment were observed at multiple depths of the cortex in two resting-state networks.

Impact: The demonstration that network connectivity does not change homogeneously in a patient population along the cortical depth suggests the importance of adding this variable to the analysis of psychiatric disorders to improve understanding of the mechanisms behind network disturbances.

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