Abstract #1257

Double Inversion Recovery in myocardial Arterial Spin Labeling (ASL) for reduced physiological noise

Maša Božić-Iven^1,2,3, Yi Zhang³, Qian Tao³, Stanislas Rapacchi⁴, Lothar R. Schad¹, and Sebastian Weingärtner³

¹Computer Assisted Clinical Medicine, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany, ²Mannheim Institute for Intelligent Systems in Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, ³Department of Imaging Physics, Delft University of Technology, Delft, Netherlands, ⁴Centre de Resonance Magnetique Biologique et Medicale, Aix-Marseille Universite, Marseille, France

Synopsis

Keywords: Arterial Spin Labelling, Arterial spin labelling, Myocardial perfusion

Motivation: Myocardial Arterial Spin Labeling (myoASL) presents a promising contrast-agent-free approach for assessing myocardial blood flow (MBF), but its clinical translation is hampered by high levels of physiological noise (PN).

Goal(s): We introduce double inversion recovery (DIR) preparations for FAIR-myoASL to mitigate sensitivity to heart rate variations and reduce PN.

Approach: A flip-back inversion pulse was added immediately after the FAIR-labeling, to allow for near-complete recovery and, thus, for more effective cancellation of the myocardial background signal in the presence of heart rate variations.

Results: Using DIR preparations in vivo, led to a PN reduction of up to 66 % compared to conventional myoASL.

Impact: FAIR-myoASL with double inversion recovery (DIR) labeling can compensate for fluctuating myocardial background signals due to heart rate variability. In vivo, experiments suggest that DIR-preparations substantially reduce PN, thus, improving overall robustness and potentially facilitating broader clinical translation of myoASL.

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