Abstract #1262

High-Fidelity ASL Perfusion Imaging Using Unsuppressed Water Signals in MR Spectroscopic Imaging

Rong Guo^1,2, Xingfeng Shao³, Yudu Li^2,4, Yibo Zhao^2,5, Wen Jin^2,5, Yao Li⁶, Danny JJ Wang³, Brad Sutton^2,4,7, and Zhi-Pei Liang^2,5

¹Siemens Medical Solutions USA, Inc., Urbana, IL, United States, ²Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ³Laboratory of FMRI technology (LOFT), USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, ⁴National Center for Supercomputing Applications, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ⁵Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ⁶School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, ⁷Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States

Synopsis

Keywords: Arterial Spin Labelling, Arterial spin labelling, Spectroscopy

Motivation: ASL and MRSI experiments are currently performed using different sequences, and EPI-based ASL methods suffer from spatial distortion and limited SNR.

Goal(s): To develop a water unsuppressed MRSI based imaging method for high-fidelity ASL-based perfusion imaging.

Approach: The SPICE sequence was integrated with a PASL module for ASL acquisition, and a GS model-based method was used for image reconstruction.

Results: The proposed method achieved ASL at 2×2×2 mm³ resolution and MRSI at 2×3×3 mm³ within 9 minutes in total. Compared with typical EPI-based methods, the resulting ASL images were free from spatial distortion, and had adequate SNR within a short scan time.

Impact: This work presents a new method for high-fidelity ASL-based perfusion imaging combining with MRSI-based metabolic imaging. With further development, it may provide a powerful brain imaging tool for both functional studies and clinical applications.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.