Abstract #1266

Validation and assessment of venous transit time in the human brain using VICTR MRI

Wen Shi^1,2, Dengrong Jiang², Zhiyi Hu^1,2, Kaisha Hazel², George Pottanat², Ebony Jones², Cuimei Xu², Vivek Yedavalli², Doris Lin², Sevil Yasar³, Yulin Ge⁴, Abhay Moghekar³, and Hanzhang Lu^1,2

¹Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²Department of Radiology & Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁴Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States

Synopsis

Keywords: Velocity/Flow, Perfusion, Transit Time, Vein

Motivation: Venous transit time (VTT) is insufficiently investigated and can be a useful marker for clinical populations with abnormalities in the cerebral venous system.

Goal(s): To further verify a novel non-contrast VICTR MRI and investigate advanced VTT properties and their age effects in the brain.

Approach: We compared the VTT from VICTR and a contrast-based method. Statistical properties of VTT distribution were studied in a caffeine challenge and compared between young and older subjects.

Results: VTT from VICTR MRI showed great agreement with contrast-based VTT. The mean, peak, and spread of VTT increased in the caffeine challenge. VTT is longer in the older subjects.

Impact: VICTR MRI can measure venous transit time in the adult brain which increases with age. The non-contrast measurement of venous transit time paves the way for several research avenues to better understand vascular function in the normal and pathological brain.

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