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Abstract #1275

DTI at four directions: an application at ultra-low field

Joshua Mawuli Ametepe1, James Gholam1, Álvaro Planchuelo-Gómez2, Francesco Padormo3, Leandro Beltrachini4, Mara Cercignani1, and Derek Kenton Jones1
1School of Psychology, Cardiff University, Cardiff, United Kingdom, 2University of Valladolid, Valladolid, Spain, 3Hyperfine Inc., Guilford, CT, United States, 4School of Physics and Astronomy, Cardiff University, Cardiff, United Kingdom

Synopsis

Keywords: DWI/DTI/DKI, Low-Field MRI, Tetrahedral Encoding

Motivation: The project aimed to tackle extended DTI scan durations, worsened by low SNR at low fields, striving to boost efficiency while preserving results' accuracy at lower SNR levels.

Goal(s): The study sought to create an ML-based approach to shorten DT-MRI scans while ensuring reliable tensor estimation despite low SNR challenges at ULF.

Approach: ML models, trained on synthetic data, predicted diffusivities and principal eigenvectors from four diffusion-weighted images, factoring in simulated noise and gradient rotations for noise and motion.

Results: The models estimated diffusivities and fibre orientations with fewer data, showing promise for ULF tractography. Suggesting shorter DTI scans are possible at ULF.

Impact: Our results are relevant to clinicians and researchers using low-field MRI, potentially enabling faster DT-MRI scans, opening avenues for efficient DTI in challenging settings, and making fibre mapping more accessible with reduced acquisition scan times.

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Keywords