Abstract #1282

Patient-specific targeting of VIM using THOMAS segmentation predicts post-MRgFUS side effects: a retrospective evaluation

Sonoko Oshima^1,2, Asher Kim^1,3, Xiaonan Richard Sun⁴, Ziad Rifi⁴, Katy A. Cross⁵, Katherine A. Fu⁵, Benjamin M. Ellingson^1,2,3,4,6, Noriko Salamon², Ausaf A. Bari⁴, and Jingwen Yao^1,2,3

¹UCLA Brain Tumor Imaging Laboratory (BTIL), Center for Computer Vision and Imaging Biomarkers, University of California, Los Angeles, Los Angeles, CA, United States, ²Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States, ³Department of Bioengineering, Henry Samueli School of Engineering and Applied Science, University of California, Los Angeles, Los Angeles, CA, United States, ⁴Department of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States, ⁵Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States, ⁶Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States

Synopsis

Keywords: MR-Guided Focused Ultrasound, MR-Guided Interventions

Motivation: Precise and personalized targeting for MR-guided focused ultrasound (MRgFUS) is desired to ensure treatment efficacy and avoid side effect.

Goal(s): To assess THalamus Optimized Multi Atlas Segmentation (THOMAS) on white-matter nulled MRI for targeting of the ventral intermediate (VIM) thalamic nucleus in MRgFUS for tremor patients.

Approach: We retrospectively assessed the relationships of standard indirectly targeted coordinates, post-FUS lesions, and THOMAS segmentation with post-FUS side effects and tremor scores in patients who underwent VIM-MRgFUS.

Results: In patients who exhibited side effects, FUS lesions had a smaller overlap with THOMAS-based VIM segmentation and were located more inferiorly.

Impact: THOMAS is a novel automated thalamic segmentation tool which may aide in the targeting of the VIM nucleus, potentially reducing side effects and improving treatment outcomes in MRgFUS for patients with tremor.

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