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Abstract #1289

EPTIMA: Echo Planar Time-resolved Imaging derived Millisecond-scale temporal resolution Acquisition

Zijing Dong1,2, Abbas Sohrabpour1,2, Lawrence L. Wald1,2,3, Jonathan R. Polimeni1,2,3, Padmavathi Sundaram1,2, and Fuyixue Wang1,2
1Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 2Department of Radiology, Harvard Medical School, Boston, MA, United States, 3Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States

Synopsis

Keywords: fMRI Acquisition, Data Acquisition, fMRI

Motivation: Achieving millisecond-scale temporal resolution MRI has the potential to provide exciting insights into fast functional/physiological processes of the brain.

Goal(s): Develop a new acquisition method, EPTIMA, that can achieve millisecond-scale temporal resolution, while improving efficiency by acquiring a time-series trial of 2D-images in a single excitation for high robustness to physiological-noise/motion.

Approach: EPTIMA captures fast temporal dynamics occurring within the readout by measuring the rate at which the baseline signal evolution is changing, and employs spatiotemporal encodings to acquire a complete time-series trial in a single-excitation.

Results: EPTIMA can image rapid electric current changes in a phantom and resolve stable phase/magnitude changes in-vivo.

Impact: A new acquisition, EPTIMA, was developed to achieve millisecond-scale temporal resolution and to image ultra-fast dynamic processes of human brain. It improves efficiency by acquiring a time-series trial of 2D-images in a single excitation with high robustness to motion/physiological noises.

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