Abstract #1295

High-Frequency Oscillation-Based Rotary Saturation: a functional imaging technique for epilepsy lateralization in MRI-negative patients

Milena Capiglioni¹, Pedro Lima Cardoso², Simon Daniel Robinson², Claus Kiefer¹, Siegfried Trattnig², Ekaterina Pataraia³, Roland Beisteiner³, and Roland Wiest¹

¹Institute for Diagnostic and Interventional Neuroradiology, Support Center for Advanced Neuroimaging (SCAN), University of Bern, Bern, Switzerland, ²High Field MR Center, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, ³Department of Neurology, Functional Brain Diagnostics and Therapy, High Field MR Center, Medical University of Vienna, Vienna, Austria

Synopsis

Keywords: Epilepsy, Bioeffects & Magnetic Fields, Spin-lock, Novel Contrast Mechanisms

Motivation: Delineation of the seizure onset zone (SOZ) in surgical planning for drug-resistant epilepsy requires invasive procedures. The Stimulus-Induced Rotary Saturation (SIRS) sequence targets biomagnetic field associated with epileptic discharges.

Goal(s): To evaluate the efficiency of SIRS in epilepsy lateralization using high-frequency oscillations (HFOs) as biomarkers and compare it with EEG and clinical seizure semiology.

Approach: We investigated 11 epilepsy patients using SIRS at a 120 Hz spin-lock frequency, assessing the localizing value at hemispheric and lobar levels.

Results: SIRS-identified activations were above threshold in 8 of 11 patients, offering potential for improved SOZ localization. Hemispheric concordance was found with EEG in 7 cases.

Impact: Spin-lock based rotary saturation imaging lateralized brain areas in epilepsy patients with negative MRI findings in concordance with EEG and seizure semiology. Combined with state-of-the-art non-invasive methods such as EEG, it offers potential for improved seizure lateralization.

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