Abstract #1296

Functional MRI of the nose

Sara Ponticorvo¹, Jaakko Paasonen², Petteri Stenroos², Ekaterina Paasonen², Pavel Filip^1,3, Douglas Rothman⁴, Edward Auerbach¹, Michael Garwood¹, Gregory J Metzger¹, Olli Gröhn², Shalom Michaeli¹, and Silvia Mangia¹

¹Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, ²A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland, ³Neurology, First Faculty of Medicine and General University Hospital, Charles University, Prague, Czech Republic, ⁴Department of Radiology and Biomedical Imaging, Magnetic Resonance Research Center (MRRC), Yale University, New Haven, CT, United States

Synopsis

Keywords: Head & Neck/ENT, fMRI (resting state)

Motivation: Standard fMRI techniques are unable to image the nasal cavity due to strong susceptibility artefacts.

Goal(s): Our goal is to exploit ultrashort or zero echo time imaging to study functional connectivity of the nose.

Approach: Resting-state fMRI was performed on 5 humans at 7T and 1 mouse at 9.4T. Independent component analysis (ICA) was performed, and ICA signals were analyzed within the context of other physiological signals.

Results: Highly reproducible nose networks were observed in humans. The signal of one network strongly correlated with the autonomic nervous system activity. A pronounced nose network was also observed in the mouse.

Impact: Ultrashort and zero echo time fMRI enables unprecedented performance for detecting functional nose networks providing the means to study nose activity and system-wide connections between central and peripheral nervous systems not currently possible with standard fMRI for the first time.

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