Abstract #1306

Multiparametric Characterization of Focal Cortical Dysplasia Using Three-Dimensional MR Fingerprinting

Ting-Yu Su^1,2, Joon Yul Choi^1,3, Siyuan Hu², Xiaofeng Wang⁴, Ingmar Blümcke^1,5, Katherine Chiprean¹, Balu Krishnan¹, Zheng Ding^1,2, Ken Sakaie⁶, Hiroatsu Murakami¹, Imad Najm¹, Stephen Jones⁶, Dan Ma², and Zhong Irene Wang¹

¹Epilepsy Center, Neurological Institute, Cleveland Clinic, Cleveland, OH, United States, ²Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, ³Biomedical Engineering, Yonsei University, Wonju, Korea, Republic of, ⁴Quantitative Health Science, Cleveland Clinic, Cleveland, OH, United States, ⁵Neuropathology, University Hospital Erlangen, Erlangen, Germany, ⁶Imaging Institute, Cleveland Clinic, Cleveland, OH, United States

Synopsis

Keywords: Epilepsy, MR Fingerprinting, Surgery, Focal cortical dysplasia

Motivation: Focal cortical dysplasia (FCD) is a common pathology in medically intractable focal epilepsy. Detecting and subtyping FCD through visual inspection of conventional MRI can be challenging.

Goal(s): We aimed to develop a multiparametric, quantitative approach for FCD characterization, based on MR fingerprinting (MRF).

Approach: High-resolution 3D MRF scans were performed in 33 epilepsy patients with FCD, 60 normal controls and 26 disease controls. A machine-learning (ML) framework based on MRF was developed to automatically classify FCD from normal cortex and separating FCD subtypes.

Results: MRF-based ML models showed high accuracies, with performances superior to the yields of clinical review.

Impact: Our approach contributes to noninvasive epilepsy presurgical evaluation, as well as an integrated clinical-pathological-imaging understanding of the FCD spectrum.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.