Abstract #1307

Comparison of multiple sclerosis and neuromyelitis optica spectrum disorder: A physiological and quantitative MRI study

Shuwan Yu¹, Zixuan Lin², Hualu Han¹, Ning Xu¹, Jiachen Liu¹, Xinyu Tong¹, Huiyu Qiao¹, Zihan Ning¹, Rui Shen¹, Mangsuo Zhao³, and Xihai Zhao¹

¹Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China, ²Department of Biomedical Engineering, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China, ³Department of Neurology, Yuquan Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China

Synopsis

Keywords: Novel Contrast Mechanisms, Brain, blood brain barrier permeability to water, oxygen extraction fraction, neuromyelitis optica spectrum disorder, multiple sclerosis

Motivation: Accurate differentiation of multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) is essential for treatment decisions and thus affects prognosis.

Goal(s): This study aimed to determine the differences of MS and NMOSD using physiological and quantitative MRI.

Approach: blood brain barrier permeability to water (PS) and oxygen extraction fraction (OEF) of all subjects were measured by physiological and quantitative MRI.

Results: The results showed that compared with healthy subjects, water PS was significantly higher in NMOSD patients, while OEF was significantly lower in MS patients. In addition, OEF was also significantly different between NMOSD patients and MS patients.

Impact: Our study demonstrated that BBB permeability to water and whole-brain oxygen extraction fraction (OEF) might be potential imaging indicators for NMOSD and MS, respectively. In addition, OEF is the key to distinguish MS from NMOSD.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.