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Abstract #1308

Evaluating simultaneously derived T2, T2*, vCBV and OEF from GE-SE EPIK in brain tumour patients

Fabian Küppers1, Mohamed Kassem1,2, Seong Dae Yun1, Christian Filss1,3, Gabriele Stoffels1, Felix Mottaghy3,4, Eline Kooi2,4, Karl-Josef Langen1, Philipp Lohmann1, and Nadim Jon Shah1,5,6,7
1Institute of Neuroscience and Medicine - 4, Forschungszentrum Juelich GmbH, Jülich, Germany, 2Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, Netherlands, 3Department of Nuclear Medicine, RWTH Aachen University Hospital, Aachen, Germany, 4Department of Radiology and Nuclear Medicine, Maastricht University Medical Center (MUMC+), Maastricht, Netherlands, 5Institute of Neuroscience and Medicine - 11, Forschungszentrum Juelich GmbH, Jülich, Germany, 6JARA-BRAIN - Translational Medicine, Aachen, Germany, 7Department of Neurology, RWTH Aachen University Hospital, Aachen, Germany

Synopsis

Keywords: Multi-Contrast, Oxygenation, Brain Tumors, Cancer, Oxygen Extraction Fraction, hybrid MR-PET

Motivation: Multi-contrast GE/SE acquisitions provide versatile, simultaneously acquired MR parameters, with fast, non-invasive OEF quantification proving potentially exceptionally valuable in clinical practice.

Goal(s): The tumour characterisation capability of 10-echo GE-SE EPIK-derived MR parameters was evaluated in standardised tumour VOIs compared to healthy brain tissue.

Approach: A full-brain 2-minute protocol was acquired from 18 tumour patients during hybrid 3T MR and FET-PET acquisitions. Quantified MR parameters were analyzed in tumour VOIs defined by FET-PET.

Results: The increased T2/T2* values and decreased vCBV/OEF obtained using 2-minute GE-SE EPIK acquisitions were in agreement with literature values.

Impact: Whole-brain T2, T2*, vCBV, and OEF quantification can be obtained within a 2-minute TA using 10-echo GE-SE EPIK MRI, revealing changes in tumour VOIs in agreement with literature values, potentially providing fast clinical access to MR parameters, especially OEF.

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Abstract

Keywords