Abstract #1317

Development of a musculoskeletal relaxometry phantom for T1, T2, and T1rho measurements

Jeehun Kim^1,2, Stephen E. Russek³, Karl F. Stupic³, Cassandra M. Stoffer³, Kathryn E. Keenan³, David Rutkowski⁴, Jeff Kammerman⁴, Jean H. Brittain⁴, and Xiaojuan Li¹

¹Program of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, Cleveland, OH, United States, ²Department of Electrical, Computer, and Systems Engineering, Cleveland ClinicCase Western Reserve University, Cleveland, OH, United States, ³National Institute of Standards and Technology (NIST), Boulder, CO, United States, ⁴Calimetrix, Madison, WI, United States

Synopsis

Keywords: Phantoms, Phantoms

Motivation: There is not a commercially available musculoskeletal (MSK) relaxometry phantom.

Goal(s): Develop a dedicated MSK relaxometry phantom for T1, T2, and T1rho measurement quality assurance.

Approach: A cylindrical phantom with 12 vials containing modulated T1 and T2 samples was created, with an MR-visible thermometer for temperature tracking. Phantom stands were used for consistent positioning. MRI/NMR measurements were collected for longitudinal stability and temperature dependence.

Results: MRI measurements were in good agreement between two vendors with CVs<3% and demonstrated longitudinal stability with CVs<3% over a 3-month period. NMR measurements showed clear changes in T1, T2, and T1rho with changing temperature.

Impact: A stable MSK relaxometry phantom prototype was successfully developed and characterized, including changes with temperature. With harmonized measurement protocols, this phantom will facilitate the use of quantitative relaxometry MRI in large-scale multi-site multi-vendor trials.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.