Keywords: Blood Vessels, Arterial spin labelling, Sickle Cell Disease, White Matter Perfusion
Motivation: Accurate white matter (WM) perfusion quantification is difficult but likely critical for assessing infarct risk in Sickle Cell Disease (SCD).
Goal(s): To evaluate the feasibility of detecting regional WM perfusion using arterial spin labeling (ASL) under conditions of high perfusion and reduced bolus arrival time (BAT) in SCD patients.
Approach: A multi-inversion time (TI; range=200-3200 ms), pulsed ASL sequence was applied to quantify perfusion detectability in SCD (n=35) and healthy (n=15) participants.
Results: WM perfusion was significantly detected for TI=800-1800 ms in SCD patients. BAT in SCD was more closely related to hematocrit (rho=0.43; p=0.01) than was WM perfusion (rho=-0.13; p=0.47).
Impact: We provide evidence in support of perfusion detection with ASL in SCD patients, which is attributable to higher perfusion and reduced BAT.
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