Keywords: Blood Vessels, Vessels, Vessel Wall; Neurovascular; Ultra-high field
Motivation: T2-weighted DANTE-SPACE is a promising sequence for intracranial black-blood vessel wall imaging at 7T. However, it is limited by signal and contrast variations and its performance versus 3T remains unclear.
Goal(s): To optimize T2-weighted DANTE-SPACE at both 3T and 7T, and to quantitatively compare their performance.
Approach: A recently introduced DANTE-SPACE simulation framework was used for protocol optimization. Data acquired from six healthy volunteers at 3T and 7T were then quantitatively compared.
Results: Optimization of DANTE-SPACE parameters at 7T provides a 24% increase in vessel visibility over a literature protocol. Contrasts at 7T are 90% higher than at 3T.
Impact: Through simulation-based optimization, the vessel wall contrasts from T2-weighted DANTE-SPACE at 7T were improved by 24% versus a literature protocol. When optimized and implemented at 3T, in-vivo data showed a much lower vessel wall contrast-to-noise relative to 7T.
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