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Abstract #1356

Discrimination Between Malignant and Healthy Breast Tissue Using Restriction Spectrum Imaging and MultiBand in a Screening Population

Stephane Loubrie1, Nicole Howard1, Summer Joyce Batasin1, Sheida Ebrahimi1, Hon J Yu1, Joshua Kuperman1, Tyler M Seibert1,2,3, Arnaud Guidon4, Haydee Ojeda-Fournier1, and Rebecca Rakow-Penner1,3
1Radiology, UCSD, San Diego, CA, United States, 2Radiation oncology, UCSD, San Diego, CA, United States, 3Bioengineering, UCSD, San Diego, CA, United States, 4Global MR Application and Workflow, GE Healthcare, Boston, MA, United States

Synopsis

Keywords: Breast, Breast, Diffusion, RSI

Motivation: Diffusion weighted imaging (DW-MRI) holds great potential in improving specificity of findings detected on contrast enhanced breast MRI. A breast-specific Restriction spectrum imaging (BS-RSI) has been developed and proved to be able to discriminate cancers from benign lesions and healthy breast tissue.

Goal(s): To evaluate BS-RSI’s performance in differentiating malignant from healthy fibroglandular tissue in a breast cancer screening dataset (BCS).

Approach: We prospectively scanned 14 BCS patients with high-resolution multishell DWI added to standard BCS clinical protocol.

Results: The BS-RSI model was able to discriminate healthy tissue from cancers in all C-compartments.

Impact: Differences were observed between healthy tissue and malignant lesions in all C-compartments (p<0.01). ADC values were also significantly different in cancers than in healthy issue (p=0.044).

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Keywords