Keywords: Microstructure, Liver
Motivation: The potential of characterizing cellular tissue microstructures using recently developed time-dependent diffusion MRI has been examined.
Goal(s): However, its value in imaging liver fibrosis to cirrhosis remains unknown.
Approach: In this study, we conducted a preclinical investigation using a dietondiethylnitrosamine (DEN)-induced rat liver fibrosis model with temporal diffusion spectroscopy (TDS) MRI
Results: Our findings revealed that the diameter, intracellular volume fraction (Vin), and cellularity were associated with varying degrees of liver fibrosis. Moreover, the diameter and Vin demonstrated better discrimination ability in the model. Overall, these prognostic indicators exhibit significant potential for clinical application.
Impact: This research highlighted the promising applications of temporal diffusion spectroscopy MRI in evaluating liver fibrosis. Our results indicated innovative noninvasive indicators for liver fibrosis, so as to early identify those who need to be referred to clinics for further assessment.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords