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Abstract #1401

MRI-based Biological Age Estimation for Multiple Organs in the UK Biobank Cohort

Veronika Ecker1,2, Marcel Früh1, Bin Yang2, Sergios Gatidis1, and Thomas Küstner1
1University Hospital of Tübingen, Tübingen, Germany, 2University of Stuttgart, Stuttgart, Germany

Synopsis

Keywords: Analysis/Processing, Aging, Biological Age

Motivation: MRI is a valuable tool for providing health-related information, including visualizing age-associated changes. Aging is influenced by chronic diseases, and assessing the true organ-specific biological age is essential for accurate diagnosis.

Goal(s): Development of an organ-specific age estimation for investigation in large imaging cohort with associated non-imaging information.

Approach: While prior studies focused on age estimation from non-imaging data or single organs, we propose a multi-organ age estimation framework, operating on brain, cardiac, and abdominal MRIs, and OCT scans.

Results: Our results prove the feasibility of imaging-based organ age estimation and initiate further investigations to identify risk factors for accelerated aging.

Impact: Reliable imaging-based estimation of biological age in multiple organ systems facilitates research efforts to identify risk factors of accelerated aging, advancing the goal of age-related phenotyping.

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