Abstract #1457

Investigation of Texture Features in Head and Neck Cancer: Preliminary Results for Early Radiation Therapy induced Changes

Victor Fritz^1,2,3, Martin Schwartz^1,4, Jens Kübler⁵, Jonas Habrich⁶, Simon Böke⁷, Daniela Thorwarth⁶, Konstantin Nikolaou⁵, and Fritz Schick¹

¹Department of Diagnostic and Interventional Radiology, University of Tuebingen, Section on Experimental Radiology, Tübingen, Germany, ²Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of Tuebingen, Tübingen, Germany, ³German Center for Diabetes Research (DZD), Neuherberg, Germany, ⁴Institute of Signal Processing and System Theory, University of Stuttgart, Stuttgart, Germany, ⁵Department of Diagnostic and Interventional Radiology, University of Tuebingen, University Hospital Tuebingen, Tübingen, Germany, ⁶Department of Radiation Oncology, University Hospital Tübingen, Section for Biomedical Physics, Tübingen, Germany, ⁷Department of Radiation Oncology, University Hospital Tübingen, University Hospital and Medical Faculty, Tübingen, Germany

Synopsis

Keywords: Cancer, Head & Neck/ENT

Motivation: Radiomic texture features are considered promising biomarkers for tumor’s response to therapy.

Goal(s): To identify texture features that can enhance predictive accuracy regarding tumor treatment outcomes.

Approach: The study included 13 patients with head and neck cancer undergoing radiation therapy, with MRI (T2w, DWI) conducted before treatment and during early-treatment phase. Image processing, tumor segmentation, and feature extraction are performed.

Results: Wilcoxon signed-rank tests with a Holm-Bonferroni correction reveals that Skewness in T2w-images exhibits significant changes during early treatment. This finding suggests that this feature may hold promise for predicting therapeutic responses, although larger studies are needed to confirm these results.

Impact: The study's preliminary findings suggest that Skewness in T2w images may have the potential to provide useful information for early response assessment in head and neck cancer patients undergoing radiation therapy, warranting further investigation to confirm its clinical significance.

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