Keywords: fMRI Analysis, Breast
Motivation: The lack of guidelines or recommendations for the ROI size of DWI and synthetic MRI.
Goal(s): To investigate the effect of different ROI positioning methods on both ADC and synthetic MRI measurements and to subsequently evaluate the diagnostic performance of differently shaped ROIs.
Approach: Four different ROI positioning methods on ADC and synthetic parameters measurements.
Results: Square ROI showed the optimal AUC followed by freehand ROI. T2 + ADC were more diagnostic than ADC or T2 alone.
Impact: The different ROI positioning methods used had a significant impact on the quantitative measurements and the performance in differentiating benign from malignant breast tumors.
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