Keywords: Breast, Breast, CEST, CEST-MRF, DRONE
Motivation: To enable quantitative CEST and MT maps in breast tissue for potential tumor characterization.
Goal(s): To explore the feasibility of simultaneously obtaining T1, T2, CEST and MT maps in breast tissue.
Approach: A CEST-MRF pulse sequence was used to measure the amide and semi-solid exchange rate and volume fractions. Quantitative maps were obtained using a neural network trained on physics-derived signals.
Results: The proposed approach yields water T1 and T2 relaxation maps, amide exchange and volume fraction maps, and semi-solid exchange and volume fraction maps in the breast in a scan time of less than 2 minutes.
Impact: Comprehensive quantitative T1, T2, amide CEST and MT bilateral breast imaging in under 2 minutes can improve the detection and characterization of breast cancer and the response to treatment in a clinical setting without the use of a contrast agent.
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