Abstract #1493

Free-breathing 3D cardiac extracellular volume (ECV) mapping using a linear tangent space alignment (LTSA) model

Wonil Lee^1,2, Paul Kyu Han^1,2, Thibault Marin^1,2, Ismael Brahim Georges Mounime^1,2,3, Samira Vafay Eslahi^1,2, Yanis Djebra^1,2, Didi Chi^1,2, Georges El Fakhri⁴, and Chao Ma^1,2

¹Department of Radiology, Massachusetts General Hospital, Boston, MA, United States, ²Department of Radiology, Harvard Medical School, Boston, MA, United States, ³LTCI, Telecom Paris, Institut Polytechnique de Paris, Paris, France, ⁴Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, United States

Synopsis

Keywords: Myocardium, Cardiovascular, Extracellular volume fraction (ECV)

Motivation: Extracellular volume (ECV) is an emerging biomarker for diffuse fibrosis, which is known to be particularly challenging to detect. Existing methods are limited to single-slice acquisition with or without breath-hold.

Goal(s): To develop a new method for free-breathing, 3D ECV mapping of the whole heart.

Approach: 3D cardiac T₁ mapping was performed before and after contrast agent injection using a free-breathing, ECG-gated IR-FLASH sequence followed by a linear tangent space alignment model-based image reconstruction.

Results: The estimated ECV values from the proposed method were comparable to those from the reference MOLLI method.

Impact: The proposed method allows for free-breathing, 3D ECV mapping of the whole heart in a practically feasible imaging time. The proposed method is potentially useful ECV quantitation in healthy and diseased populations with diffuse fibrosis.

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