Abstract #1508

Ferumoxytol-enhanced Cardiac MRI for Delineation of Intramyocardial Hemorrhage

Arutyun Pogosyan¹, Caroline M. Colbert^1,2,3,4, Mary J. Keushkerian¹, Gregory A. Fishbein⁵, Jesse W. Currier¹, J. Paul Finn^3,4, and Kim-Lien Nguyen^1,3,4

¹Division of Cardiology, David Geffen School of Medicine at UCLA and VA Greater Los Angeles Healthcare System, Los Angeles, CA, United States, ²Radiation Oncology, University of Washington, Seattle, WA, United States, ³Physics and Biology in Medicine Graduate Program, University of California Los Angeles, Los Angeles, CA, United States, ⁴Radiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States, ⁵Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States

Synopsis

Keywords: Myocardium, Myocardium, hemorrhage, intramyocardial hemorrhage, myocardial infarction, ischemia-reperfusion injury, ischemia , animals, blood, blood vessels, cardiovascular, contrast agents, contrast mechanisms, heart, novel contrast mechanism, preclinical

Motivation: Intramyocardial hemorrhage (IMH) frequently occurs in acute myocardial infarction (AMI) and is associated with adverse outcomes. While T₂* cardiac magnetic resonance (CMR) imaging has emerged as the reference standard for noninvasive IMH detection, it relies on the paramagnetic properties of hemoglobin breakdown products, usually detectable between 1 and 3 days following IMH.

Goal(s): We demonstrate an alternative approach that can more promptly detect active myocardial bleeding.

Approach: We leveraged the T₁ shortening effects of intravascular ferumoxytol to identify IMH following acute ischemia-reperfusion injury.

Results: Ferumoxytol-enhanced CMR depiction of IMH were in agreement with gross and histologic evaluations.

Impact: We demonstrate the effectiveness of ferumoxytol-enhanced cardiovascular magnetic resonance (FE-CMR) in detecting active intramyocardial hemorrhage after ischemia-reperfusion injury. This may facilitate the development, testing, and clinical adoption of strategies to mitigate IMH-associated complications.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.