Keywords: Myocardium, Heart, Myocardial infarction，Patch，Cardiac magnetic resonance
Motivation: Evaluation of therapeutic effect of myocardial infarction（MI） patch using cardiac magnetic resonance （CMR） imaging
Goal(s): Cooperation between medicine and polymer science
Approach: We made a pig model of MI. The MI pigs in the patch group attached the patch to the epicardial side, while the MI pigs in the control group were not treated. We performed CMR imaging before operation, 2 weeks and 8 weeks after modeling. Finally, the heart was taken for pathological verification.
Results: Compared with the control group, the patch group pig had thicker ventricular wall, better cardiac function and smaller LGE%. Histology and imaging correspond well.
Impact: By non-invasively analyzing the heart's structure and function, CMR helps us evaluate the potential of using patches to treat MI and offers valuable insights for preventing ventricular aneurysms after heart attacks in clinical practice.
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