Keywords: Bone, Bone, Ultra High Field, 7T, knee, bone marrow, pTx RF pulse, spatial-spectral RF pulse design, water excitation, fat supression
Motivation: To make knee bone marrow arterial spin labeling (ASL) imaging a viable and clinically practical approach.
Goal(s): To increase knee bone marrow ASL imaging signal-to-noise efficiency and quality by using parallel transmit spatial-spectral localized water excitation pulses for ASL image readouts.
Approach: Spatial-spectral water excitation pulses inside a 2D arbitrarily-shaped region of interest were designed and validated in a knee phantom and healthy volunteers using an 8-channel transceiver knee coil.
Results: The designed spatial-spectral pulses could produce localized water excitation inside targeted regions with effective fat suppression.
Impact: The validated pulse design provides an effective way for localized water excitation and eliminate the need for additional fat saturation with reduced RF power deposition, having a great potential to improve knee ASL imaging efficiency at ultrahigh field.
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