Keywords: Muscle, Muscle
Motivation: Looking for a convenient tool to detect the skeletal muscle fiber atrophy non-invasively in the early stage of diabetic sarcopenia.
Goal(s): This study aims to assess the pathological changes in skeletal muscle of diabetic sarcopenia rats using muscle MR texture analysis.
Approach: Type 1 diabetic sarcopenia rat model was conducted via STZ intraperitoneal injection. 2D MR texture features of the gastrocnemius muscle were extracted, followed by histopathological examination using HE stains.
Results: Muscle MR texture features exhibited significant differences between the diabetic sarcopenia group and the control group, and demonstrated a strong correlation with pathological characteristics of skeletal muscle fibers.
Impact: Texture features derived from muscle MR images show potential for non-invasively identifying skeletal muscle atrophy in diabetic sarcopenic rats and providing insights into underlying disease mechanisms.
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