Keywords: Cartilage, Cartilage, sodium MRI, 23Na, IVD, lumar Spine, lower pack pain, ex vivo, quantitative imaging
Motivation: The global impact of lumbar back pain requires an understanding of degenerative disc disease. Conventional MRI often misses early changes, necessitating a more sensitive technique for accurate detection.
Goal(s): To determine the efficacy of 3T-MRI with 23Na in accurately assessing degeneration to provide a deeper understanding of the correlation between sodium concentrations and proteoglycan levels in intervertebral discs.
Approach: Examination of human lumbar spine samples ex vivo using a 23Na-surface-coil, which enabled accurate determination of 23Na relaxation times and quantification of tissue sodium concentrations (TSCs).
Results: Results showed a significant correlation between decreasing TSC values and progression of Thompson grading.
Impact: This exciting research represents a significant advance in the field of lumbar disc degeneration assessment and promises to be an important part of a paradigm shift in diagnostic approaches and treatment strategies for patients with lumbar back pain.
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