Keywords: Traumatic Brain Injury, Traumatic brain injury
Motivation: It is important to understand how neurotrauma accelerates the progression of Alzheimer's disease.
Goal(s): The project's goal is to use ultra-high isotropic resolution (60μm) diffusion-MRI for exploring changes in white matter integrity after neurotrauma.
Approach: Ex vivo diffusion-MRI was acquired using a 9.4T Bruker scanner in a transgenic mouse model of Alzheimer's disease with and without neurotrauma.
Results: We observed decreased quantitative anisotropy in mice 8 months post the brain injury.
Impact: Our preliminary finding demonstrated that neurotrauma can induce accelerated white matter degeneration in Alzheimer's disease.
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