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Abstract #1617

Quantitative UTE MRI of Demyelination in mTBI Mice Subject to Open-field Low-intensity Blast Injury

Yajun Ma1, Qingbo Tang1,2, Jiyo S Athertya1, Xin Cheng1,2, Roland Lee1,2, Mingxiong Huang1,2, Eric Y Chang1,2, Catherine E Johnson3, Jiankun Cui4, Zezong Gu4, and Jiang Du1,2,5
1Radiology, UC San Diego, La Jolla, CA, United States, 2VA San Diego Healthcare System, La Jolla, CA, United States, 3Department of Explosive Engineering, Missouri University of Science and Technology, Rolla, MO, United States, 4Pathology and Anatomical Sciences, University of Missouri, Columbia, MO, United States, 5Bioengineering, UC San Diego, La Jolla, CA, United States

Synopsis

Keywords: Traumatic Brain Injury, Traumatic brain injury

Motivation: mTBI can lead to myelin damage, culminating in substantial cognitive function impairment. Yet, conventional neuroimaging methodologies often fall short in identifying abnormalities in a significant proportion of mTBI instances.

Goal(s): To assess the potential of UTE sequence in detecting demyelination in mTBI mice subject to an open-field LIB injury.

Approach: A new STAIR-UTE sequence was employed to study demyelination in mTBI mice subject to an open-field LIB injury at 3T.

Results: The STAIR-UTE measured MPFs in the corpus callosum region for the mTBI mice are significantly lower (8.5±0.4% vs. 8.8±0.4%; p-value = 0.0055) than those for the control mice.

Impact: STAIR-UTE sequence enables quantitative myelin imaging at 3T MRI, facilitating the detection of demyelination within the mouse brain's white matter following open-field LIB exposure. This innovative STAIR-UTE technique holds significant promise for in vivo mTBI diagnosis and treatment monitoring.

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Abstract

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