Keywords: Traumatic Brain Injury, Traumatic brain injury, repetitive head impacts
Motivation: Neurodegenerative changes in the cortical sulci and gyri have been associated with repetitive head impacts (RHI) but have only been observed post-mortem.
Goal(s): To detect sulcal and gyral extrema white matter microstructure changes in vivo.
Approach: Automated image-analysis algorithms were used to average the fractional anisotropy (FA) of sulcal fundi and gyral crowns in a cohort of amateur adult soccer players and age- and sex- matched non-collision amateur athletes.
Results: We found soccer players’ FA was significantly lower within the fundi and crowns of the frontal, orbitofrontal, temporal regions, as well as the cingulate and parietal regions for fundi only.
Impact: Here we report the first in vivo imaging study demonstrating white matter microstructure changes within sulci and gyri due to RHI. We anticipate our approach to be a starting point for more sophisticated use of DTI to study RHI effects.
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