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Abstract #1622

Overcoming challenges of quantitative susceptibility mapping in moderate-to-severe TBI patients

Juan F. Domínguez D.1, Ashley Stewart2, Alex Burmester1, Hamed Akhlaghi3, Kieran O’Brien4, Steffen Bollmann5, and Karen Caeyenberghs1
1Cognitive Neuroscience Unit, Deakin University, Melbourne, Australia, 2School of Information Technology and Electrical Engineering,, The University of Queensland, Brisbane, Australia, 3Department of Emergency Medicine, St. Vincent’s Hospital, Melbourne, Australia, 4Siemens Healthcare, Brisbane, Australia, 5Centre for Advanced Imaging, The University of Queensland, Brisbane, Australia

Synopsis

Keywords: Quantitative Imaging, Quantitative Susceptibility mapping, lesion filling, individualised profiling

Motivation: Quantitative susceptibility mapping (QSM) is being increasingly used to investigate pathophysiological changes in traumatic brain injury (TBI). However, generating artefact-free quantitative susceptibility maps in brains with large focal lesions, as in the case of moderate-to-severe TBI (ms-TBI), is particularly challenging.

Goal(s): To generate artefact-free quantitative susceptibility maps in moderate-to-severe TBI patients with large focal lesions.

Approach: We utilized a novel two-pass masking technique and reconstruction procedure in combination with a recently developed virtual brain grafting tool for brain repair.

Results: Our innovative approach allowed us to generate artefact-free personalised QSM profiles of individual ms-TBI patients with reference to a sample of healthy controls.

Impact: We outline an approach to obtain magnetic susceptibility values in the presence of large focal lesions and provide a framework to generate personalised QSM profiles that may be used by clinicians to characterise TBI pathophysiology or implement neuroscience-guided rehabilitation programs.

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Keywords