Keywords: Quantitative Imaging, Quantitative Susceptibility mapping, lesion filling, individualised profiling
Motivation: Quantitative susceptibility mapping (QSM) is being increasingly used to investigate pathophysiological changes in traumatic brain injury (TBI). However, generating artefact-free quantitative susceptibility maps in brains with large focal lesions, as in the case of moderate-to-severe TBI (ms-TBI), is particularly challenging.
Goal(s): To generate artefact-free quantitative susceptibility maps in moderate-to-severe TBI patients with large focal lesions.
Approach: We utilized a novel two-pass masking technique and reconstruction procedure in combination with a recently developed virtual brain grafting tool for brain repair.
Results: Our innovative approach allowed us to generate artefact-free personalised QSM profiles of individual ms-TBI patients with reference to a sample of healthy controls.
Impact: We outline an approach to obtain magnetic susceptibility values in the presence of large focal lesions and provide a framework to generate personalised QSM profiles that may be used by clinicians to characterise TBI pathophysiology or implement neuroscience-guided rehabilitation programs.
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