Keywords: Myocardium, Cardiomyopathy, Myocardial Strain; Hypertrophic cardiomyopathy(HCM); Mechanical function
Motivation: To identify potential imaging markers for early detection of hypertrophic cardiomyopathy (HCM) .
Goal(s): To evaluate mechanical dysfunction in HCM mice with different genotypes representing different disease stages.
Approach: Myocardial circumferential strain, radial strain, longitudinal strain, and torsion were assessed using two distinct strain assessment methods: feature tracking and tagging MRI.
Results: The results showed a significant reduction in myocardial strain in severe HCM, but an intriguing trend of slight elevation was observed before a decline in strain occurred in mild HCM, highlighting the potential value of these markers in the early detection of HCM.
Impact: Myocardial contractile function is significantly reduced in hypertrophic cardiomyopathy (HCM). However, our study suggests the presence of a compensatory phase during disease progression. Early identification of myocardial contraction dysfunction is vital for prompt detection and treatment, ultimately improving patient outcomes.
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