Abstract #1694

MRI relaxometry techniques combined with MAIT cell parameters for the assessment of disease activity in axial spondyloarthritis (axSpA)

Shengsheng Yang¹, Yonghong Zheng¹, Xianyuan Chen¹, Mingui Lin², Xiaomin Dai¹, Fei Gao³, Huangjing Chen¹, Mingping Ma¹, Shun Yu¹, and Yang Song⁴

¹Shengli Clinical Medical College of Fujian Medical University; Radiology department of Fujian Provincial Hospital, Fuzhou, China, ²Radiology department of, Fuzhou Second Hospital, Fuzhou, China, ³Shengli Clinical Medical College of Fujian Medical University; Rheumatism department of Fujian Provincial Hospital, Fuzhou, China, ⁴MR Research Collaboration Team, Siemens Healthineers Ltd., Shanghai, China

Synopsis

Keywords: Bone, Relaxometry, Axial spondyloarthritis, T1 mapping

Motivation: Currently, there is a lack of an objective quantitative measure to comprehensively evaluate the inflammatory activity of axSpA, which poses certain challenges in accurately assessing the disease activity.

Goal(s): To establish a more reliable combined-parameter model for assessing the inflammatory activity of axSpA.

Approach: T1 mapping values, T2* mapping values and the frequency of MAIT cells and CD69⁺MAIT cells are constructed into single-parameter and combined-parameter models using logistic regression. The diagnostic efficacy was evaluated by employing the ROC curves.

Results: The model combining T1 mapping with CD69+MAIT cells showed relatively superior diagnostic efficacy in differentiating the severity of axSpA disease activity.

Impact: The combined-parameter model incorporating T1 mapping and CD69+MAIT cells provided an effective objective quantitative indicator for evaluating the inflammatory activity of axSpA.

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