Abstract #1704

Integrated CrCEST MRI and Downfield MR Spectroscopy to Achieve Muscle Specific OXPHOS Measurement with Personalized Exercise Regimes

Ryan R Armbruster¹, Dushyant Kumar², Blake Benyard¹, Paul Jacobs¹, Fang Liu³, Aditi Khandavilli⁴, Ravi Prakash Reddy Nanga², Neil Wilson², Shana McCormack⁵, Anne Cappola⁵, and Ravinder Reddy²

¹Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, United States, ²Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, ³Department of Biostatistics, University of Pennsylvania, Philadelphia, PA, United States, ⁴Department of Nutrition and Science, Cornell University, Ithaca, NY, United States, ⁵Division of Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, PA, United States

Synopsis

Keywords: CEST / APT / NOE, CEST & MT

Motivation: CrCEST measurements are sensitive to the changes in muscle pH, which confound the measurement and interpretation of τCr. Our motivation was to develop a technique that removed acidic bias from CrCEST measurements to ensure OXPHOS measurement.

Goal(s): Develop a personalized mild exercise technique that limits acidosis in the calf to ensure measurement of OXPHOS using CrCEST.

Approach: To test the dependence of CrCEST recovery time on pH with different exercise regimes.

Results: Carnosine ¹HMRS can be used to quickly measure pH change induced by a prescribed exercise regime and can facilitate an unbiased measurement of personalized muscle group specific OXPHOS capacity with CrCEST.

Impact: Carnosine ¹HMRS can be used to quickly measure pH change induced by a prescribed exercise regime and can facilitate an unbiased measurement of personalized muscle group specific OXPHOS capacity with CrCEST.

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