Abstract #1713

Disorganized Thalamic Subregional Functional Connectivity in Bipolar Disorder

Xipeng Long¹, Xiuli Wang², Yuan Cao³, Di Kong², Baolin Wu⁴, Hongsheng Xie³, Ziru Zhao³, Neil Roberts⁵, Qiyong Gong⁶, and Zhiyun Jia³

¹Department of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China, ²Department of Psychiatry, the Fourth People’s Hospital of Chengdu, Chengdu, China, ³Department of Nuclear Medicine, West China Hospital of Sichuan University, Chengdu, China, ⁴Department of Radiology, West China Hospital of Sichuan University, Chengdu, China, ⁵University of Edinburgh, Edinburgh, United Kingdom, ⁶Department of Radiology, West China Xiamen Hospital of Sichuan University, Xiamen, Fujian, China, Chengdu, China

Synopsis

Keywords: Psychiatric Disorders, Psychiatric Disorders

Motivation: Compared to cortical regions, the involvement of functional connectivity of subcortical regions in bipolar disorder (BD) are less well known.

Goal(s): The potential involvement of subcortical and subregions of thalamus are explored in BD.

Approach: Seed-based subcortical and thalamic subregional functional connectivity was compared between the BD patients and HCs, as well as between patients with BD type I (BD-I) subgroup and HCs as a sub-group analysis.

Results: BD patients showed increased functional connectivity between left thalamus and right lingual gyrus, between right anterior thalamus and superior frontal gyrus, and between right ventral anterior thalamus and precuneus.

Impact: These findings provide evidence of disorganized thalamo-cortical functional connectivity in BD, suggesting that the thalamus and its subregions may play important and specific roles in the neural circuitry of BD.

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