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Abstract #1740

A study of quantitative susceptibility mapping on cerebral oxygen metabolism in patients with insomnia

Ruifang Xiong1, Hanting Zhu1, Chengyi Li1, Pengxin Hu1, Yu Zou1, and Xiaoping Tang1
1Department of Radiology, The Second Clinical Medical College of Nanchang University, Nanchang, China

Synopsis

Keywords: fMRI Analysis, Quantitative Susceptibility mapping

Motivation: Abnormalities in cerebral oxygen metabolism can occur in many brain disorders. Cerebral venous oxygen saturation (CSVO2) allows the assessment of cerebral oxygen metabolism in patients with insomnia and thus indirectly reflects brain function.

Goal(s): This study aimed to explore alterations in cerebral oxygen metabolism in patients with insomnia.

Approach: CSVO2 in patients with insomnia and healthy controls was measured by 3D-slicer on quantitative susceptibility mapping (QSM). Statistical analysis was conducted using SPSS.

Results: Cerebral oxygen metabolism was lower in insomnia patients than in healthy controls, which was associated with sleep efficiency, R-phase share, and total sleep time.

Impact: Our study shows the impact of insomnia on cerebral oxygen metabolism and the ability to assess cerebral function noninvasively by QSM, which is useful in prompting early clinical intervention.

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