Keywords: Vessels, Heart, NMR spectroscopy
Motivation: Heart valve disease (HVD) is a multifactorial process and its pathophysiology has not been fully understood.
Goal(s): To investigate and determine the metabolite tissue using the 1H-NMR based metabolomics study to discriminate the aortic valve and mitral valve.
Approach: proton NMR spectroscopy
Results: The results obtained from PLS-DA and VIP score plots of metabolites in tissue showed a separation between patients with aortic valves and mitral valves.
Impact: The present study revealed discrimination of metabolic profiling of tissue of aortic valve patients from mitral valve replacement implying that 1H-NMR-based metabolomics may provide an insight into understanding the potential metabolic alteration.
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