Abstract #1779

Free-running, Ferumoxytol-Enhanced Cardiac High-Dynamic-Range QSM (HDR-QSM) for Motion-resolved Myocardial Blood Volume Quantification

Yuheng Huang^1,2, Xingmin Guan¹, Xinheng Zhang^1,2, Archana Malagi³, Chia-chi Yang³, Li-Ting Huang³, Xinqi Li³, Ghazal Yoosefian¹, Anthony Christodoulou^3,4, Debiao Li³, Hui Han⁵, Rohan Dharmakumar¹, and Hsin-Jung Yang³

¹krannert cardiovascular research center, Indiana University School of Medicine, Indianapolis, IN, United States, ²Bioengineering, UCLA, LA, CA, United States, ³Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, LA, CA, United States, ⁴Department of Radiological Sciences, David Geffen School of Medicine at UCLA, LA, CA, United States, ⁵Radiology, Weill Cornell Medicine, New York, NY, United States

Synopsis

Keywords: Myocardium, Cardiovascular, Quantitative Susceptibility Mapping (QSM); Myocardial Blood Volume(MBV)

Motivation: Myocardial Blood Volume (MBV) is an important factor in the progression of cardiac pathologies.

Goal(s): We proposed to combine a motion-resolved cardiac high-dynamic-range quantitative susceptibility mapping (HDR-QSM) approach with ferumoxytol (an iron-based intravascular contrast agent) to accurately measure myocardial blood volume (MBV).

Approach: HDR-QSM was prescribed in pigs with and without AMI after ferumoxytol administration to investigate the cyclic MBV changes and infarct-induced MBV redistribution in AMI.

Results: Significant MBV difference was observed between systolic and diastolic phases between healthy and infarcted hearts.

Impact: Ferumoxytol-enhanced cardiac QSM has the potential to accurately quantify motion resolved MBV in healthy and diseased hearts.

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