Abstract #1819

Evaluation of Local Microstructural Gradients in the Myocardium of Subjects with Severe Aortic Stenosis.

Christopher Rock^1,2, Iris Y. Chen², Anne L. Philip¹, Boris Keil^2,3, Christopher T. Nguyen^2,4,5, and David E. Sosnovik ^1,2,5

¹Cardiovascular Research Center, Mass General Hospital, Boston, MA, United States, ²A.A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, ³Institute of Medical Physics and Radiation Protection, TH Mittelhessen University of Applied Sciences, Geissen, Germany, ⁴Cardiovascular Innovation Research Center, Heart, Vascular, and Thoracic Institute, Cleveland Clinic, Cleveland, OH, United States, ⁵Health Sciences and Technology Program, Harvard - Massachusetts Institute of Technology, Cambridge, MA, United States

Synopsis

Keywords: Myocardium, Radiomics

Motivation: Diffusion tensor imaging of the heart can be performed with sub-mm resolution. However, established metrics do not fully take advantage of this improved resolution.

Goal(s): We aimed to determine whether local gradients in helix angle (HA) could be calculated and used to characterize the microstructural response of the heart to the load imposed by aortic stenosis.

Approach: Voxel-wise maps of radial, circumferential, minimum and maximum HA gradients were generated.

Results: The radial HA gradient was reduced in aortic stenosis, but microstructural coherence was well preserved in these patients despite a marked increase in the thickness of the myocardium.

Impact: DTI of the heart with sub-mm in-plane resolution allows maps of local HA gradients to be generated, providing novel insights into the microstructure of the heart.

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