Meeting Banner
Abstract #1821

Exploring age-related alterations in brain metabolite levels in healthy adult women using 1H MRS at 3T: Effects of exposure to early-life stress

Ralf Mekle1, Lara Fleck2, Martin Bauer2, Dinesh K. Deelchand3, Claudia Buss2,4, Sonja Entringer2,4, Jochen B. Fiebach1, Matthias Endres1,5,6, and Christine Heim2,5
1Center for Stroke Researech Berlin (CSB), Charite Universitätsmedizin Berlin, Berlin, Germany, 2Institute of Medical Psychology, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany, 3Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, United States, 4Development, Health, and Disease Research Program, University of California, Irvine, Orange, CA, United States, 5Neurocure Cluster of Excellence, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt- Universität zu Berlin, Berlin, Germany, 6Department of Neurology with Experimental Neurology, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

Synopsis

Keywords: Spectroscopy, Neuro, early-life stress, adverse childhood experiences, age-related, brain metabolites

Motivation: Adversity experienced during early life termed early-life stress (ELS) might increase the risk for neuroinflammation and neurodegenerative disorders in the adult human brain. An enhanced understanding of these relationships will aid in diagnosis and intervention.

Goal(s): Our goal was to investigate whether ELS is associated with changes in brain metabolism by using 1H MR spectroscopy.

Approach: The interaction between metabolite concentrations obtained from MRS, acquired in adult women, age, and scores of ELS was modeled using non-linear statistics.

Results: Higher concentrations with increasing age in individuals exposed to ELS were found for specific metabolites suggesting long-term effects of ELS on the human brain.

Impact: Understanding the role of early-life stress (ELS) in driving neuroinflammatory processes and identification of specific biomarkers to assess the risk for accelerated cognitive decline and neurodegenerative disorders in individuals exposed to ELS will aid in early identification and targeted interventions.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Abstract

Keywords