Keywords: Spectroscopy, Molecular Imaging, functional MRS, schizophrenia, redox, glutathione
Motivation: Redox imbalance in schizophrenia may help to explain the full range of observable schizophrenia symptoms.
Goal(s): Our goal was to use a more appropriate tool to measure dynamic changes in neurometabolites in schizophrenia compared to traditional MRS techniques.
Approach: We used functional MRS with a cognitive Stroop task to investigate glutathione dynamics as well as associated glutamate and glutamine dynamics.
Results: Glutathione levels increased during task and stayed elevated for healthy subjects, but not for patients.
Impact: By demonstrating abnormal anterior cingulate cortex glutathione response to short-term cognitive battery in first-episode schizophrenia, we offer novel support and added framework behind potential redox imbalances in schizophrenia and their utility in managing symptom treatment.
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