Abstract #1848

Water-cycled STEAM spectroscopy in the liver at 7T

Erin McConnell Montoya¹, Ferenc Emil Mózes², Jack J. J. J. Miller^2,3, and Ladislav Valkovič^2,4

¹Department of Physics, University of Oxford, Oxford, United Kingdom, ²OCMR, RDM Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom, ³The MR Research Centre and the PET Centre, Aarhus University, Aarhus, Denmark, ⁴Department of Imaging Methods, Institute of Measurement Science, Slovak Academy of Sciences, Bratislava, Slovakia

Synopsis

Keywords: Spectroscopy, High-Field MRI

Motivation: Hepatic choline-containing compounds (CCC) are an important biomarker of metabolic health.

Goal(s): The aim of this work is to measure the concentration of fat and choline-containing compounds in the liver using water-suppression cycled (WSC) and water suppressed (WS) spectroscopy at 7T.

Approach: Livers of seven healthy volunteers were scanned using water-suppression cycling and the results were compared with standard water-suppressed acquisitions.

Results: Similar concentrations of CCC were reported for both techniques, with WSC providing somewhat narrower line widths. Hepatic fat fractions were also very close using each method validating WSC as a method for use at 7T.

Impact: Frequency-aligned spectra from water-suppression cycled acquisitions enable the quantification of low-concentration metabolites in vivo at 7T.

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