Keywords: Spectroscopy, High-Field MRI, Metabolism, Neuro
Motivation: 7T MRI is adversely affected by inhomogeneity in the B1 transmit field. In MRSI applications, this can manifest as spatial variability in water-suppression and signal excitation, which may adversely affect quantification.
Goal(s): To use B1+ shimming to decrease the inhomogeneity of the transmit field and improve water suppression and metabolite quantification in RS-COKE MRSI.
Approach: B1+ shim weights for all RF pulses were optimised using magnitude least-squares and data compared with a circularly polarised mode acquisition.
Results: Metabolite quantification showed greater consistency, lower error estimates and improved water-suppression efficiency, in some subjects, when B1+ shimming was applied to the RS-COKE MRSI sequence.
Impact: The use of B1+ shimming in RS-COKE MRSI improves the quantification of metabolite concentrations in some subjects. This increased robustness will allow for its application to patient populations in future clinical research.
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