Abstract #1854

Analysis of MRS voxel placements in brain tumors performed by MRS experts

Sangyoon Lee^1,2, Francesca Branzoli³, Ovidiu Andronesi⁴, Clark Chen⁵, Alexander Lin⁶, Roberto Liserre⁷, Gerd Melkus⁸, Thanh Nguyen⁸, Patrick Bolan¹, and Małgorzata Marjańska¹

¹Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, United States, ²Department of Radiation Oncology, University of Minnesota, Minneapolis, MN, United States, ³Paris Brain Institute, ICM, Sorbonne University, Paris, France, ⁴Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States, ⁵Department of Neurosurgery, University of Minnesota, Minneapolis, MN, United States, ⁶Center for Clinical Spectroscopy, Department of Radiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United States, ⁷ASST Spedali Civili University Hospital, Brescia, Italy, ⁸Department of Radiology, Radiation Oncology and Medical Physics, University of Ottawa, Ottawa, ON, Canada

Synopsis

Keywords: Spectroscopy, Spectroscopy

Motivation: There is no standardized way of prescribing MRS voxels in the lesion. This depends entirely on the MR operator’s expertise and opinion.

Goal(s): Our goal was to analyze MRS voxel placements in brain tumors for quantitatively reliable and reproducible voxel placement.

Approach: MRS experts placed voxels and visually scored their placements. Placements and scores were compared to tumor characteristics.

Results: All experts showed a tendency to place the voxels to fill approximately 30% of voxels with tumor core for different participants. The fraction of tumor core in voxels showed a correlation of 0.76 to the fraction of tumor core in the whole tumor.

Impact: Quantitative analysis of MRS voxel placement shows that MRS experts deemed a voxel properly placed when tumor core was adequately included, suggesting widely applicable and objective method of voxel placement and assessment for non-experts in clinical settings.

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