Keywords: Neurotransmission, Metabolism, Spectroscopy, Brain, Animal
Motivation: Electroconvulsive shock (ECS) therapy is an established treatment for drug-resistant depression. However, the status of neurometabolic activity during ECS-induced seizure is not clear.
Goal(s): This study was carried out to measure neurometabolic activity during ECS-induced Seizure.
Approach: 1H-[13C]-NMR spectroscopy was used in conjunction with intravenous [1,6-13C2]glucose or [2-13C]acetate infusion to measure neuronal and astroglial metabolic activity, respectively.
Results: The neurometabolic activity was increased while astroglial activity remained unchanged during ECS-induced seizure. Moreover, the anaerobic glucose consumption was highly increased, suggesting the dominance of glycolysis during the seizure state.
Impact: The assessment of metabolic activity of Glutamatergic, GABA’ergic neurons, and astrocytes during ECS-induced seizures, provides valuable information about glucose consumption during enhanced energy demand, and the interplay of different cell types in the brain.
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