Keywords: Head & Neck/ENT, Spectroscopy, Precision and accuracy, brain, tinnitus
Motivation: The measurement of GABA+ using in vivo proton magnetic resonance spectroscopy requires adequate reproducibility and reliability for its use in clinical research and as a potential biomarker.
Goal(s): We aimed to determine the within-session test-retest reproducibility and reliability of GABA+ in the auditory cortex of individuals with tinnitus.
Approach: A MEGA-sLASER sequence for GABA+ measurement using two consecutive within-session blocks was performed on 38 participants over 2 scanning days.
Results: GABA+ quantification in the auditory cortex demonstrated similar reproducibility and reliability when using either a total creatine (tCr) or water reference (GABA+/tCr: CV=5.6%, ICC=0.69, 95% CI [0.52-0.80]; GABA+/water: CV=5.6%; ICC=0.73, 95% CI [0.58-0.83]).
Impact: Auditory cortex GABA+ quantification with MEGA-sLASER in a clinical population with GABA+ abnormalities in the region of interest can be achieved with reproducibility and reliability that is comparable to what has been reported in other brain regions of healthy controls.
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