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Abstract #1946

Synthetic-based histogram analysis associated with depth of invasion predicted progression-free survival in nasopharyngeal carcinoma

Fan Yang1, Haoran Wei1, Xiaoduo Yu1, Lizhi Xie2, Meng Lin1, and Hongmei Zhang1
1Department of Diagnostic Radiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China, Beijing, China, 2GE Healthcare, MR Research China, Beijing, Beijing, China

Synopsis

Keywords: Head & Neck/ENT, Head & Neck/ENT, Nasopharyngeal carcinoma; Depth of Invasion; Synthetic MRI

Motivation: Deeply infiltrating tumors have a poor prognosis and need close follow-up. Whether the depth of invasion could serve as a quantitative prognostic indicator in NPC. The prognostic assessment value of synthetic MRI (SyMRI) needs further analysis.

Goal(s): To explore the value of two quantitative methods in prognostic assessment in NPC, including depth of invasion and SyMRI.

Approach: This study prospectively included NPC patients, and utilized multiple statistical methods to construct and validate two methods.

Results: Depth of invasion and SyMRI are important quantitative methods.

Impact: Tumor invasion depth is an unignorable metric, and combining it with SyMRI may provide a quantitative and objective approach for clinical treatment.

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